Small-scale Biomanufacturing

A new technical paper is available from Integra Biosciences that discusses and compares the use of different types of disposable cell culture systems for the manufacturing of biological products in mammalian cells. The paper describes the historical development of two-compartment cell cultivation bioreactors and introduces the advantages of using the CELLine 1000 bioreactor for the production of monoclonal antibodies up to yields of 1000 mg. A cost analysis, including the expenses from disposables, equipment amortisation, medium, serum and labour, is presented for the production of 200mg of antibodies comparing the CELLine 1000 with roller bottles and a stirred bioreactor.