Epidermal Skin Test

CellSystems introduces a new easy-to-use epidermis model for pharmaceutical and chemical compound testing. The cellular structure of EST-1000 resembles that of natural epidermis showing a base membrane, proliferating keratinocytes and stratum corneum with an intact barrier function. Toxic or irritating effects of test substances can be determined by multiple end-point analysis including viability, histology and cytokine release. The epidermis model is supplied in a convenient 12-well format to facilitate topical application of test substances. Due to legal restrictions for animal testing, three dimensional in-vitro models are increasingly used to measure effects of skin-active substances. Some years ago the company had already introduced the first full-thickness skin model AST-2000.