MDS Analytical Technologies announced the launch of the Molecular Devices SpectraMax M3 and M4 Multi-Mode Microplate Readers. These two new systems were designed specifically in response to requests from users of SpectraMax Readers. By offering two new configurations of multi-mode readers that deliver increased capabilities over the M2/M2e Dual-Mode Readers at a more affordable price than the M5/M5e Multi-Mode Readers, it can now meet a great combination of detection, application, and budgetary needs. The M3 and M4 readers are designed as modular systems to ensure easy upgrade paths. The M3 provides three detection modes: UV-Vis absorbance, fluorescence intensity, and luminescence, but can be upgraded to include time-resolved fluorescence and/or fluorescence polarization modes. The M4 additionally offers plus time-resolved fluorescence, and can be upgraded to include fluorescence polarization. All SpectraMax Readers are built on a dual-monochromator platform. In addition, these readers enable well-volume detection via the patented PathCheck Sensor and superior optical capabilities via a patented Smart Optics Design. All readers accommodate a cuvette as well as six-well to 384-well standard microplates and leverage the SoftMax Pro data acquisition and analysis software.