Next Generation of Single-Use Bioreactor Technology

Dasgip, supplier of Parallel Bioreactor Systems, announced the integration of its Dasgip Control System with the Thermo Scientific HyClone Single-Use Bioreactor (S.U.B.) at Biotechnica 2008 in Hanover, Germany.

The HyClone S.U.B. platform combines traditional stirred tank reactor design with the benefits of disposable bag technology. Based on a reusable stainless steel outer support structure and a sterile Thermo Scientific HyClone BioProcess Container (BPC) the S.U.B. delivers ease-of-use functionality coupled with the highest level of process safety available for mammalian cell culture. The risk of cross contamination is minimised as are the related process qualification and validation procedures since neither cleaning nor sterilisation are required.

With the Dasgip Control System platform seamlessly integrated into the Thermo Scientific HyClone S.U.B. product line, transition from the traditional glass benchtop bioreactors associated with process development to the pilot plant applications associated with the S.U.B. with one control platform is possible. All set-point and process values, including speed and temperature, can be accessed through the Dasgip Control platforms user interface.

In addition to the online monitoring of pH, dissolved oxygen and optional optical density, the use of the Dasgip Control System platform with the Thermo Scientific ­HyClone S.U.B. allows for the precise control of up to four individual gasses by means of mass flow controllers. Additionally, over pressure detection and gas flow cut-off is integral to the offering as is gas mixing ratios and the ability to flow gas to headspace and/or sparge.