Microcarrier Cell Culture

TAP Biosystems has developed a new method of using microcarriers with its Ambr micro bioreactor system. This technique enables scientists to produce uniform microcarrier samples and perform automated media exchange to rapidly optimise parameters for culturing adherent cell lines on microcarriers, thus shortening timelines for successfully scaling up manufacturing of vaccines and cell therapies.

Scientists at the company have utilized the workstation to develop an automated method for providing highly consistent dispensing of microcarriers to multiple 10-15 ml ambr microbioreactors. This means scientists can then rapidly test up to 24 cell-specific culture parameters in parallel including stirring, media formulation or feed strategies to determine the optimum conditions for cell attachment, growth rate and vaccine titer, for example.