Continuous Reflective Interface Sample Placement (Crisp) substantially eliminates focus drift in high power microscopy by sensing minute changes between the objective lens and the specimen’s cover slip, and then providing a feedback signal to any of ASI’s focus controllers, or existing piezo focusing devices. The Crisp system provides high-level focus stability allowing a specimen to remain accurately focused for hours at a time with a focus accuracy of 5% of the objective depth of focus, and will also maintain focus while scanning. The Crisp module adapts to the C-mount port of nearly all microscopes with a DCMS beam splitter.