02/09/2009 • Focus on Products at Analytica

Combatting LDEV

BD Biosciences is now able to deliver all variants of BD Matrigel Basement Membrane Matrix from a guaranteed LDEV-free tumour source. It is suited for all in vivo applications in mice, in particular for tumour research (e.g. BD Matrigel Plug Assay). Routine quality control of BD Matrigel Matrix includes testing for bacteria, fungi, mycoplasma as well as more than 35 pathogens, including LDEV. Lactate dehydrogenase-elevating virus (LDEV) is one of the biggest threats for mouse breeding facilities. The virus infects macrophages and influences the immune response, eventually leading to erroneous results in transgenic or knock-out animals. The virus does not infect any other species than mice, nor does it infect other cells than macrophages. Purified extracellular matrix products are usually sourced from a tumour cell line (Engelbreth-Holm-Swarm Tumour) which is propagated in mice.

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