Continuous Flow Synthesis

Raising the reaction temperature achievable with the Flowsyn Continuous Flow Reactor from Uniqsis has considerably widened the scope of reactions that can be performed, say manufacturers Uniqsis of Cambridge. Reactions can now be carried out at up to 260ºC and pressures up to 1000psi (~70 Bar). High activation energy chemistries that might previously have required a catalyst or the use of a microwave reactor are now potential candidates for continuous flow synthesis, with its attendant benefits better reproducibility and scalability and fewer problems with unstable intermediates or unexpected exotherms. Other improvements include easier pump priming and refinements to the automated reaction control so that the user can control the amount of the pre- and post-plug dispersion phases that are collected with their steady state reaction product.