COMU ….The Ultimate Coupling Reagent !

Peptide production in either solid or liquid phase technologies consume vast amounts of coupling reagents. Some are allergenic, some are suspected as flammable, some possess an explosive nature (facts which influence both transportation and use).

Luxembourg Biotechnologies ltd, sought for “the ultimate product”, one which would serve in most peptide production modes while having favourable “cost-effectivenes“, being applicable for industrial use, and exposing coupling reagent users with minimal negative side effects. In the light of the above, and in close collaboration with the research groups of Professor Fernando Albericio (Barcelona, Spain (2)) and Professor. Ayman El-Faham (Alexandria, Egypt), Luxembourg Biotechnologies Ltd. (Rehovot, Israel) has been continuously promoting and supporting the development of new reagents, aimed at eliminating the problems described above. Differential thermal analysis and ARC studies recently carried out, have shown that the new class of reagents, including COMU, are not explosive under normal operating conditions and, importantly, allergic reactions such as contact dermatitis or asthma are drastically reduced or eliminated. Apart from the obvious health and production benefits associated with the new reagents, their chemical benefits are most impressive, exceeding expectations.

The introduction of a proton accepting moiety (the morpholino group) into the structure of COMU allows the use of one equivalent of base during the coupling protocol, thus contributing to reduction of racemization in the growing peptide chain without impairing the reaction rate or the overall yield of the coupling process.

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