Tecan has recently developed the Quad Chamber for fully automated processing of four different microarrays simultaneously on one slide, using the HS Pro automated hybridisation station. The instrument was developed for use with Agilents new 4 x 44k 4-Plex Gene Expression as well as CGH Microarrays, which consist of four individual, whole-genome microarrays printed on a single glass slide. This represents the first fully automated system that can independently handle four arrays on one slide with no cross-contamination between the arrays. The system provides a completely sealed environment around each of the four arrays on Agilents 4-Plex slides, with independent channels for wash buffers, independent agitation mechanisms and drying for each of the four areas.