Bruker AXS has introduced the compact and affordable Smart X2S (Crystal-to-Structure), the first benchtop X-ray crystallography system for fully automated three-dimensional (3D) chemical structure determination. It is designed for use by chemists who have no special training in crystallography and it is expected to appeal to many inorganic and organic chemists at colleges and universities, as well as in bio-pharma and chemical companies. Traditional X-ray systems for 3D structure determination are floor-standing, require significant infrastructure and typically are installed in specialist X-ray crystallography centers. Weighing less than 70 kg and requiring only 0.5 kW of standard single-phase AC power, the system can be installed easily in any academic or industrial chemistry laboratory.