Even the most rapid biological processes can now be captured at ultra high resolution as a result of the launch of a new range of confocal laser scanner systems by Nikon Instruments. Two models are available; the fully automated A1 and the high specification A1R. The A1 utilises conventional paired galvonometers producing high resolution images (up to 4096 x 4096 pixels), whilst the A1R incorporates a hybrid scanner system (offering frame rates of 30fps, 512 x 512 pixels). This facilitates ultra-high-speed imaging with very high image quality. Furthermore, the hybrid scanner enables simultaneous photo-activation and imaging, critical for unveiling cell dynamics and interactions. The new systems are a complement to the recently launched Ti inverted microscope.