Dynamic In Vivo Imaging with Leica FCM1000

Non-invasive, real-time imaging at high resolution anywhere in the living animal can now be conducted with the new Leica FCM1000 endoscopic confocal microscope.

The innovative fiber-optic confocal fluorescence microscope Leica FCM1000 was developed by Leica Microsystems partnering company Mauna Kea Technologies in Paris and is fully adapted to in vivo and in situ small animal imaging.

Imaging live tissue in its physiological environment is now as simple as placing the microprobe in contact with the site of interest. The flexibility and minute diameters of the Leica FM Microprobes enable endoscopic access to any location in the living animal. Exceptional full-field frame rate ensures high image stability as well as smooth and precise positioning of the field of view.

The system fully meets the requirements of experiments in pre-clinical research where longitudinal imaging of patho-physiological processes and straightforward quantification of data play a central role, e.g. in nerve fiber density quantification, in diabetes or tumor anti-angiogeneic drug evaluation.