CELLine
The CELLine bioreactor is a disposable, two-compartment cultivation device. It is perfectly suited for a wide range of applications involving suspension cell culture, like monoclonal antibody production or long-term continuous culture maintenance. The unit is optimised for cultivation of hybridoma, CHO (Chinese hamster ovary) cells, NSO (mouse myeloma) cells, SF (Spodoptera frugiperda, insect cells) cells and many more.
High Cell Density Cultivation With the two-compartment technology of CELLine, deficiencies in nutrition or oxygenation are problems of the past. Therefore, cell densities inside the cell compartment are usually between 107 to 108 cells per ml which is about two magnitudes higher than with conventional static cell culture techniques.
High product concentrations Benefiting from the high cell densities, product concentrations achieved in CELLine are in the range of 1 to 5 mg per ml, making the bioreactor most suitable for antibody expression in hybridomas, protein expression in transfected cell lines, or virus production. Product concentrations in the cell compartment of CELLine are in most cases 50–100 times above those found in static cell culture disposables, such as flasks and roller bottles.
Long-term, continuous culture maintentance Separate access to the medium compartment of CELLine allows for continuous delivery and efficient oxygenation of the cells, thus enabling the user to perform continuous studies on a specific cell culture, or to benefit from a consistent protein production over several weeks.
High Cell Density Cultivation With the two-compartment technology of CELLine, deficiencies in nutrition or oxygenation are problems of the past. Therefore, cell densities inside the cell compartment are usually between 107 to 108 cells per ml which is about two magnitudes higher than with conventional static cell culture techniques.
High product concentrations Benefiting from the high cell densities, product concentrations achieved in CELLine are in the range of 1 to 5 mg per ml, making the bioreactor most suitable for antibody expression in hybridomas, protein expression in transfected cell lines, or virus production. Product concentrations in the cell compartment of CELLine are in most cases 50–100 times above those found in static cell culture disposables, such as flasks and roller bottles.
Long-term, continuous culture maintentance Separate access to the medium compartment of CELLine allows for continuous delivery and efficient oxygenation of the cells, thus enabling the user to perform continuous studies on a specific cell culture, or to benefit from a consistent protein production over several weeks.
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