MALDI Tissue Imaging: Bringing Masses to Imaging Applications
Bruker Daltonics will host a web seminar and two exclusive live product demonstrations in April and May 2007. Convince yourself of the power of this new technology for your application and reserve your participation today:
Imaging mass spectrometry is a label-free technique that reveals the spatial distribution of proteins and peptides within an intact tissue slice. With a re-solution better than 50 nanometers, mass spectra from the surface of the tissue slice are acquired. Hundreds of proteins can be seen simultaneously in the mass range of 2100 kilodaltons and are clearly displayed in a color-coded mass image (fig. 1) using the latest MALDI mass spectrometer (MALDI imaging).
Being a revolutionary new technology for cancer research and drug development, advanced MALDI imaging demands superior technology: Fast and high-resolution mass spectrometers, superior smart laser technology for the MALDI process, and sophisticated software and evaluation tools.
Yet, superior results in mass imaging are directly dependent on sample preparation. Prior to mass analysis, the tissue slice is covered with a thin matrix layer enabling the MALDI ionisation process. This is a critical step, as it determines spectra quality and thus resolution, quantity of both protein and peptide signals and reproducibility. A new device, the ImagePrep station from Bruker Daltonics achieves all these criteria in a completely automated fashion. With the ImagePrep station, a comprehensive solution for MALDI imaging is available from Bruker ranging from high resolution sample preparation to superior mass spectrometry and sophisticated software tools.
Imaging mass spectrometry is a label-free technique that reveals the spatial distribution of proteins and peptides within an intact tissue slice. With a re-solution better than 50 nanometers, mass spectra from the surface of the tissue slice are acquired. Hundreds of proteins can be seen simultaneously in the mass range of 2100 kilodaltons and are clearly displayed in a color-coded mass image (fig. 1) using the latest MALDI mass spectrometer (MALDI imaging).
Being a revolutionary new technology for cancer research and drug development, advanced MALDI imaging demands superior technology: Fast and high-resolution mass spectrometers, superior smart laser technology for the MALDI process, and sophisticated software and evaluation tools.
Yet, superior results in mass imaging are directly dependent on sample preparation. Prior to mass analysis, the tissue slice is covered with a thin matrix layer enabling the MALDI ionisation process. This is a critical step, as it determines spectra quality and thus resolution, quantity of both protein and peptide signals and reproducibility. A new device, the ImagePrep station from Bruker Daltonics achieves all these criteria in a completely automated fashion. With the ImagePrep station, a comprehensive solution for MALDI imaging is available from Bruker ranging from high resolution sample preparation to superior mass spectrometry and sophisticated software tools.
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