Farewell to Focus Drift

One of the biggest obstacles to acquiring meaningful live cell time-lapse data has been swept away thanks to the launch of the new real-time focus facility on the Nikon TE2000-PFS motorized inverted microscope. This now offers Drift-Free imaging to research experiments involving live cells, by eliminating variables such as thermal change of chambers or those caused by the microscope itself in long-term or high-speed time-lapse observation. Now consistent focus can be maintained for observations of days or more by simply focusing on the desired plane, and then turning PFS on. Stable in-focus observations over an extended period of time are possible with the TE2000-PFS as it automatically detects the surface of the coverslip optically and continually corrects the focus to compensate for even the most infinitesimal changes. This means that researchers no longer have to adjust the focus knob every time stage movement occurs, or after adding reagents.